This article summarizes research findings on the health-beneficial effects of α-ketoglutarate in maintaining intestinal homeostasis and explores
the associated underlying mechanisms.

Introduction: Alpha-ketoglutarate (AKG) is a naturally occurring metabolite that plays a central role in cellular metabolism. In recent years, there has been growing interest in the potential role of AKG in regulating fertility and fecundity. Animal studies have shown that AKG supplementation can improve fertility in both males and females,...